Interaction of Diamino Oxidase with Psychostimulant Drugs for ADHD Management

Histamine intolerance occurs when there is an imbalance between histamine production and the capacity for degradation. Diamine oxidase (DAO) main enzyme catabolism of ingested degradation in gastrointestinal tract its deficiency has been linked to allergy-like symptoms. Psychostimulant drugs are commonly used treat Attention Deficit Hyperactivity Disorder (ADHD), but their interaction with DAO not well characterized. In this work, we evaluated effects psychostimulant (methylphenidate lisdexamfetamine) on vitro activity human cell line enterocytes (Caco-2), evaluating expression (mRNA protein) activity. Methylphenidate lisdexamfetamine did repress addition, Caco-2 cells, promoted a strong upregulation mRNA levels, whereas methylphenidate tended induce To sum up, treatments do reduce These findings could be useful physicians prescribing these two ADHD patients affected by deficiency.